Chapter 407 Depressing Aspen Firm

Stockholm Airport, amongst a bunch of yellow-haired and white-skinned folks, there are two Chinese language people who find themselves significantly apparent.

White folks passing by took a number of additional glances at them and heard them converse English. Though their garments weren’t extravagant, they have been neat and beneficiant. They thought they have been from Bangzi Nation or Japanese.

In spite of everything, Chinese language folks have been nonetheless uncommon right now. Even when they have been seen, they might be recognized simply by the Chinese language tunic swimsuit and critical facial features.

Lan Lijuan requested about some amenities at her husband’s airport and the nationwide circumstances of Sweden in English that she was not too conversant in.

Chen Qi held his spouse’s hand tightly, and whereas strolling to get the bags, he additionally answered his spouse’s inquiries in English.

Since Xiangjiang began connecting planes, Chen Qi requested Lan Lijuan to speak in English the entire time, whether or not it was between the 2 of them, or going to a comfort retailer to purchase one thing, or colluding with a flight attendant.

After graduating from technical secondary faculty, Lan Lijuan studied English each day with the encouragement of her boyfriend Chen Qi.

Later, Chen Qi additionally took benefit of the chance of going overseas to purchase loads of video tapes in English, together with motion pictures and TV reveals, simply to let his spouse apply her spoken English.

After all the video is a critical video, there isn’t a shouting: “mygod”, “comeonbaby”

After a number of years, Lan Lijuan has been in a position to totally learn English periodicals and supplies, however oral English has at all times been her weak spot. In spite of everything, it’s nonetheless troublesome to study oral English in an English atmosphere.

Simply by watching the video, I can totally perceive what I heard, however it nonetheless takes loads of effort to talk.

Simply benefiting from this chance to go to Sweden, Chen Qi determined to let his spouse’s spoken English rapidly catch up.

It doesn’t matter what period, those that say that English training isn’t necessary, and even push the nation to abolish the primary English topic in major and secondary faculties, are both silly or unhealthy.

Chen Qi is now the favored spicy rooster of ICPF, and what he enjoys is VIP pick-up remedy.

When the couple got here to the exit, the organizers of the ICPF annual assembly have been already ready. After shaking palms, they acquired into the automotive and drove rapidly in the direction of the lodge.

Sure, Chen Qi primarily got here to Sweden to attend the ICPF annual assembly this time, and he got here early, and didn’t come out with the Hua Guo delegation.

As a result of he got here to Sweden this time, along with attending the annual assembly, he additionally had a non-public itinerary, which was additionally the explanation why he took Lan Lijuan to go overseas.

That’s for his spouse’s profession, he wants to debate a cooperation with the Swedish Asrila Pharmaceutical Firm.

Presently, on the headquarters of Asrila Firm, Chairman Denilson was trying on the newest drug produced by the corporate with a frown.

This can be a abdomen medication. To be able to develop this medication, the corporate has been researching for 15 years from 1970 to 1986.

The funds invested have amassed as much as 500 million US {dollars}.

Asrila, among the many many pharmaceutical firms in Europe and the US, can solely be thought to be second-rate at greatest. The corporate’s funds aren’t too wealthy, and the five hundred million US {dollars} will kill the corporate.

Relating to pharmaceutical analysis and growth, there’s a “rule of 10”, that’s, spend 10 years, make investments 1 billion US {dollars}, and have a ten% success charge.

So R&D funds account for almost all of pharmaceutical firms, and eat up a lot of the income. In consequence, among the many 10 topics studied, only one was profitable ultimately.

If this drug is profitable, it could be in a monopoly place, and your drug is exclusive on this planet, then you’ll make a fortune.

If all 10 analysis subjects fail, sorry, the corporate will bear the loss.

However Aslila didn’t have such good luck.

As a result of he developed a abdomen medication, and all through the Nineteen Seventies and Eighties, there have been two medicines that dominated the abdomen illness market on this planet, one was cimetidine and the opposite was ranitidine.

These two mainstream medicine compete very fiercely with one another.

The issue is that the boss and the second are engaged in competitors, and infrequently the third and fourth are completed first.

So Denilson may be very troubled. How can the drug produced by his firm compete with cimetidine and ranitidine?

You could know that cimetidine is produced by SmithKline, whereas ranitidine is produced by Glaxo, each of that are pharmaceutical giants in England.

Neither the dimensions of the corporate nor product advertising and marketing is similar to the second-tier firm Asrila.

What’s extra horrible is that the drug newly invented by Asrila is identical sort of gastric acid suppression drug as cimetidine and ranitidine.

Though the laboratory report obtained by Denilson is for certain, the newly invented drug is way stronger than ranitidine or cimetidine by way of acid suppression.

However so what?

How one can get sufferers to just accept a brand new drug in order that they’re keen to pay for it includes the problem of how you can market it, which requires loads of promoting prices and shopping for a lot of high worldwide gastroenterologist platforms.

That is one other enormous expense, and Denilson does not have the braveness to battle the 2 large pharmaceutical giants.

And there may be one other drawback of Asrila’s new drug, that’s, their analysis and growth prices are too excessive, which leads them to extend the worth of the drug. The present worth is 10 occasions that of ranitidine.

Even when your healing impact is healthier than ranitidine, however your worth is 10 occasions that of it, apart from the wealthy, most people will certainly select cheaper medicine.

Why is the price of the brand new Asriella drug so excessive? It may well solely be stated that it is a product stuffed with disasters.

In 1970, AstraZeneca launched a gastrointestinal analysis program, meaning to inhibit gastric acid secretion by way of comparable synthesis of anesthetics. Based mostly on lidocaine, this analysis synthesized quite a lot of associated compounds.

The compound did have a superb impact on gastric acid suppression in rats, however it was later discovered that compound H81/75 was ineffective on people, which made the analysis virtually stranded.

By 1972, the gastric acid suppression challenge was restarted with a brand new technique, and a compound CMN131 was developed to inhibit gastric acid secretion, and it was discovered that this compound had acute toxicity.

Sure, the challenge can solely proceed to review.

In 1973, Asrila Firm found the comparatively secure benzimidazole H124/26, however sadly, this compound has been lined by different firms’ patents, and it was ineffective once more.

After lastly creating the metabolite H83/69, it was discovered that there’s long-term power toxicity that causes goiter and thymus atrophy.

Lastly, it’s crucial to change the construction of H83/69 once more, thus acquiring the compound H149/94.

This time it was efficiently developed. It may be seen that the method is troublesome. Any drawback in any step could result in the failure of your entire challenge.

The appliance for a brand new drug was submitted in 1980, entered the substantive experimental stage in 1982, and the product was finalized in 1986.

For 15 years of analysis and growth, it price a complete of 500 million U.S. {dollars}. Bear in mind, this was 500 million U.S. {dollars} within the Nineteen Seventies and Eighties, which is able to kill Aslila.

Asrila Chairman Denilson sat in the primary seat, listening to the experiences of his subordinates.

“We now have determined to take part within the World Pharmaceutical Exhibition held in China, and we’ll do our greatest to market it on the convention. The plan is as follows…”

“We now have reached a cooperative relationship with Professor Segel of Karolinska College Hospital, and he’ll assist us promote the newest medicine at this 12 months’s Worldwide Society of Gastroenterology…”

“We additionally plan to take a position 20 million US {dollars} in European Sens, and spend money on promoting in main nations…”

The experiences from the subordinates turned an increasing number of optimistic, however Denilson had a headache as a result of none of those ideas was new.

What he wants is a blockbuster, explosive publicity, and a singular perspective in order that the general public can rapidly keep in mind and perceive this drug.

However the promotion plans supplied by my subordinates are the identical as boiled frogs in moist water. Not solely are they not revolutionary, however they’re additionally very formulaic.

For instance, the sponsors behind the “Worldwide Society of Gastroenterology” are both Glaxo or Smith Kline. Solely these two large canines within the discipline of gastric medication can spend some huge cash.

“Worldwide Society of Gastroenterology” (WCOG), that is the world’s mainstream medical affiliation, with greater than 50,000 members worldwide, and hundreds of individuals collect at every annual assembly.

When it comes to scale and affect, it’s not similar to major faculties equivalent to ICPF or FSSH.

The 2 pharmaceutical giants have spent some huge cash to sponsor this convention, and they’re going to undoubtedly give preferential remedy to the abdomen medication promotion of those two firms. How can it’s the flip of Asrila?

Equally, the merchandise of those two firms have lengthy been broadly used clinically, they usually have additionally established good cooperative relations with a few of the most well-known digestive illness consultants and docs on this planet.

This sort of relationship has loads of advantages to export, and it wants to offer loads of {dollars}, which is equal to an “alliance relationship”.

That is a particularly robust community, and pharmaceutical firms and well-known docs are all communities of curiosity.

Now Asrila needs to intervene horizontally, which is equal to a 3rd occasion intervening, and the potential for success is comparatively small, as a result of the wealthy and highly effective folks give cash readily and provides extra.

Combating for monetary assets? Asrila is the youthful brother.

When Aslila was anxious in regards to the promotion of latest merchandise, Chen Qi and Lan Lijuan had already arrived on the lodge.

Professor Dewey, the president and vp of the ICPF Society, Prof. Johnson from England, and Prof. Hashimoto Takeshi from Japan are already ready.

It’s unattainable for the three presidents to attend for the subordinate administrators for some time in different societies. When an individual reaches a sure stage, he should take note of his fashion.

However there isn’t a manner, Chen Qi is basically superb. From the start of the three new cleft lip and palate surgical procedures that amazed the venue, to the earlier “tubular rhinoplasty”, they’re all pioneering surgical procedures.

He’s so highly effective, and humble, and keen to separate his achievements from others. Such a superb man with out ambition is worthy of the varied presidents of ICPF to win over and set up a superb private relationship.

Particularly Professor Hashimoto Ken, when he noticed Chen Qi coming in, he went up and gave him a hug:

“Chen Sang, you’re late, we’ve been ready for you for a very long time, haha, Physician Lan, we meet once more.”

Lan Lijuan additionally hurriedly smiled and nodded in greeting: “Professor Hashimoto, I by no means anticipated to see you once more so quickly.”

Ken Hashimoto stayed within the Fourth Hospital of Yuezhong for two weeks for tubular nostril surgical procedure. To be able to set up a friendship with Chen Qi, he typically went to Chen Qi’s home to have dinner, so he was very conversant in Lan Lijuan.

Dewey had been to Huaguo twice earlier than, and he was no stranger to Chen Qi’s spouse, so he took the initiative to say hi there:

“Chen, your lovely spouse might be afraid of you messing round outdoors, so she got here to oversee you personally. It is over, I dare not invite you to the bar tonight.”

Chen Qi blinked: “It is okay, I can sneak out whereas my spouse is asleep.”

hahaha~~~~

After some joking, the ambiance of a number of folks was harmonious, and Dewey pulled Chen Qi to the facet of a tall white man:

“Chen, that is Professor Segel from Karolinska College Hospital in Sweden. He’s additionally essentially the most well-known gastroenterologist in Sweden. He has an excellent relationship with Asrila Prescribed drugs. The colleagues within the clinic helped to introduce it.”

Interpersonal relationships are so ingenious.

You do not know folks, however you possibly can go round a number of occasions and at all times discover the folks you want. That is the good thing about having connections.

Chen Qi thought to himself, it truly is Dr. Mayo who’s primary on this planet, so he simply helped to introduce a “intermediary”, and he was searching for the highest physician in his nation.

“Good day, Professor Segel, it’s a nice honor to satisfy you. Let me introduce, that is my spouse, who can be a doctor in our nation. She as soon as revealed an article within the “Lancet” journal in 1983. Bacillus” paper.”

Professor Segel’s eyes lit up when he heard this:

“Ha, I’ve learn this paper, it is very revolutionary, however now the controversy appears to be very large, the primary controversy is that even when this sort of micro organism is discovered, there isn’t a technique to show its pathogenicity, and there’s no technique to kill it Unknown micro organism.”

Clearly, this Professor Segel can be an “previous otaku”. As quickly as he meets his friends, he instantly discusses educational points.

That is clearly what Chen Qi likes.

So he took a step again, highlighted his spouse’s place, and gave her an encouraging look.

Lan Lijuan took a deep breath, suppressed the strain in her coronary heart, and replied in English:

“Good day, Professor Segel, my present experiments in China have been in a position to verify the pathogenic precept of this bacterium, and the related papers have been accomplished, and I’m going to proceed to submit them to The Lancet.

And we’re additionally searching for an answer that may fully kill the micro organism within the gastric mucosa. For this reason my husband and I got here to Sweden, so we’re very wanting to get your assist. “

“What? That is unimaginable, can it actually verify the pathogenic components of those unknown micro organism?”

Professor Segel appeared like he was alive. He’s a high gastroenterologist, and he understands that if this argument could be confirmed, it’s going to have nice scientific significance.

It may be stated that it has subversive significance within the historical past of digestive illnesses on this planet.

Lan Lijuan was very critical: “It is true, and my husband and I got here to Sweden this time to discover a drug that may kill this unknown bacterium.”

Professor Segel wished to proceed asking questions, however Dewey subsequent to him rapidly interrupted:

“Hey, I stated, are you going to have an educational assembly within the foyer? Segel, Chen and his lovely spouse are already very drained after flying for greater than ten hours. Let’s go and have a relaxation first.”

Professor Segel clearly cannot wait.

(finish of this chapter)